The value of laboratory indicators estimation in patients with metabolically healthy obesity: analysis of a clinical case with literature review

Introduction. Obesity currently is a relevant issue of modern medicine due to its global prevalence, heterogeneity clinical and laboratory manifestations, as well the association with various comorbid conditions. Depending on metabolic status, metabolically unhealthy obesity (MUO) healthy (MHO) are distinguished. MUO defined presence criteria for syndrome (MS) associated an increased risk cardiovascular complications. MHO characterized by «metabolically healthy» profile, but probability favorable course disease controversial; many studies indicate instability phenotype possibility further development MUO. The aim study: analyze features indicators determine factors example case. Materials methods. A case 24 year old female patient diagnosed alimentary-constitutional class III. Objectively: height – 174 cm, weight 124.7 kg, body mass index (BMI) 41.21 kg/m2, waist circumference 107 hips 144 cm; white striae abdomen; excessive subcutaneous fat stores, mostly distributed in abdomen, thighs; blood pressure (BP) 125/80 mm Hg. Investigation data: hyperleptinemia 86.82 ng/ml, level HOMA 4.6, hyperuricemia 6.8 mg/dl, vitamin D deficiency 9.19 ng/ml; lipid fasting plasma glucose, glycated haemoglobin (HbA1c), thyroid stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), anti-thyroid peroxidase (anti-TPO) antibodies, cortisol, electrolytes, liver function tests within normal limits. Electrocardiography (ECG), ultrasound heart abdominal organs without pathology. Results. Normal metabolism, glucose BP measurement our characteristic MHO. However, combination insulin resistance, D3 hormonal imbalance considered MS transition Conclusion. should be transient state, management such patients requires careful monitoring early detection disorders adequate timely correction.